Newborns with mild hypoxic-ischemic encephalopathy usually do not receive cooling treatment. However, some of these newborns may develop neurological problems later in life. This observational study aims to evaluate whether early brain monitoring and measurements of brain oxygen levels are associated with neurological outcomes in newborns with mild hypoxic-ischemic encephalopathy. Newborns will be monitored during the first 72 hours after birth as part of routine clinical care. Neurological assessments will be performed during early infancy and later follow-up. The findings of this study may help improve early risk assessment and support closer monitoring of newborns who may be at increased risk for unfavorable neurological outcomes.
Blood gas criteria
pH ≤ 7.00 or base deficit ≥ 16 mmol/L
An acute perinatal event, and
Apgar score ≤ 5 at 10 minutes or ongoing resuscitation at 10 minutes of life, including the need for positive pressure ventilation.
Normal neurological examination Newborns with a completely normal neurological examination according to Sarnat and Sarnat staging.
Moderate or severe encephalopathy within the first 6 hours of life
Clinical findings consistent with moderate or severe encephalopathy during the first 6 hours after birth.
Presence of clinical seizures.