Prednisone for CRPS in Distal Radius Fracture
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19+
SponsorUniversity of British Columbia
About this trial
Wrist fractures are the most prevalent adult fracture. Complex regional pain syndrome (CRPS) is a common complication that can occur, leading to permanent disability and is costly to the patient and healthcare system. In addition, amidst the opioid epidemic, the risk of increased opioid use in patients with CRPS prompts the need to find viable treatment strategies. This study aims to evaluate an anti-inflammatory medication, prednisone, in the early treatment of CRPS. Patients with wrist fractures who undergo surgical treatment will be randomized to receiving placebo vs prednisone for 2 weeks. Clinical assessments in the follow up period will be compared.
Eligibility criteria
Qualifiers
Patient is aged 19 years or older;
Patient has a unilateral, closed, distal radius fracture confirmed by radiographs;
The fracture is acute, within 21 days of injury;
Patient undergoes open reduction internal fixation with volar locking plate;
Disqualifiers
Patient has previously fractured ipsilateral wrist;
Patient has neurovascular injury associated with distal radius fracture;
Patient has associated extremity or polytrauma injuries that would interfere with rehabilitation and outcome measurements, in the opinion of the investigator;
Patient has allergy to prednisone or placebo ingredients;
Trial design
Treatments tested in this trial
- Prednisone
- Placebo
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of British Columbia
Lead sponsor
Canadian Orthopaedic Foundation
Collaborator
Source ClinicalTrials.gov