This is a phase III randomized trial with the aim to compare preoperative HSRS to postoperative HSRS in patients with large at least one BMs from solid tumors suitable for surgical resection.
Age >18 years
Histological or cytological or radiological confirmation of solid tumor malignancy
Clinical indication for surgical resection of one brain metastasis
Karnosky performance status (KPS) ≥70
Prior WBRT
KPS < 70
Diagnosis of small cell lung cancer (SCLC), germinal cell tumour or Lymphoproliferative disease
Pregnant women
Istituto Clinico Humanitas
Lead sponsor
Brainlab AG
Collaborator