Preoperative vs Postoperative Revascularization in Coronary Heart Disease Patients Undergoing Time-Sensitive Non-Cardiac Surgery (CHRONOS-PCI)

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorFirst Affiliated Hospital of Wenzhou Medical University

About this trial

To compare the safety and efficacy of preoperative versus postoperative revascularization strategies in patients with coronary heart disease undergoing time-sensitive non-cardiac surgery.

Eligibility criteria

Qualifiers

Age ≥18 years

Diagnosis of coronary heart disease with non-emergent indication for PCI confirmed by coronary angiography:

Non-ST-elevation acute coronary syndrome (NSTE-ACS) at low or intermediate ischemic risk

Moderate or severe stenosis of the left main coronary artery

Disqualifiers

Age >80 years

Severe thrombocytopenia (platelet count <50×10⁹/L)

Cardiogenic shock, severe heart failure (NYHA class IV, Killip class IV, or LVEF ≤35%), malignant arrhythmias (including cardiac arrest, asystole, ventricular fibrillation, or sustained ventricular tachycardia), or other life-threatening conditions requiring resuscitation

Moderate-to-severe valvular heart disease, high-grade atrioventricular block, or other severe cardiac/pulmonary dysfunction incompatible with the planned surgery

Trial design

Treatments tested in this trial

  • Non-cardiac surgery followed by postoperative PCI
  • Preoperative PCI followed by delayed non-cardiac surgery ~3 months later

Treatment groups

140 Participants
are divided into 2 treatment groups