About this trial
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management and improve patient outcomes. Parameters of the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy) of the MostCare system, specifically cardiac cycle efficiency has been proposed as such variables. Yet, their value in anesthesia and especially in hypertensive patients is not studied. The goal of the PRAM-in-HYPO study is to prospectively evaluate the relationship between cardiac reserve and efficiency and cardiovascular risk factors in patients wo will undergo major surgical procedures using the state-of-the-art hemodynamic monitors. Also the investigators aim to build a predictive model to identify patients with decreased cardiac reserve due to hypertension and other cardiovascular risk factors, who are susceptible to post-induction hypotension. The investigators seek to include high-risk patients or patients presenting for major surgery, who are monitored with an advanced hemodynamic monitor to adequately evaluate the differences in cardiac reserve and cardiac efficiency.
Eligibility criteria
Qualifiers
Age at least 18 years
Undergoing major surgery under general anesthesia
Expected surgery time >2 h
Expected length of postoperative stay >2 d
Disqualifiers
Refuse to consent to the study
Arterial wave form distortion
Cardiac arrhythmia
Inappropriate identification of the dicrotic notch for any reason
Trial design
Treatments tested in this trial
- Passive leg raising
Treatment groups
Sponsors and collaborators
Recep Tayyip Erdogan University
Lead sponsor
Turkish Society of Thoracic and Cardio-Vascular Anesthesia and Intensive Care
Collaborator