Pressure-Volume Loop Assessment in Valvular Heart Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNantes University Hospital
About this trial
The VHD PV loop study intends to assess invasive right ventricular to pulmonary artery (RV-PA) coupling in patients with valvular heart disease (VHD). Invasive RV-PA coupling is measured by using conductance catheters, the gold standard assessment for ventricular physiology. Several non-invasive parameters have been reported as surrogates for this complex physiological entity, but none of them has been tested against the gold-standard in this population. Based on this, our main objective is to assess the correlation of imaging derived RV-PA coupling in comparison to the invasive measurement.
Eligibility criteria
Qualifiers
Adult patients (≥ 18 years old);
Heart failure with moderate-to-severe or severe secondary mitral regurgitation
At least severe tricuspid regurgitation
Significant pulmonary valve stenosis and/or regurgitation
Disqualifiers
Patients under legal guardianship or protection (e.g., guardianship, trusteeship, or any other legal protection measure);
Pregnant or breastfeeding women;
Vulnerable individuals (e.g., persons deprived of liberty, adults under legal protection);
Known proximal venous occlusion of the superior or inferior vena cava territory
Trial design
Treatments tested in this trial
- Observational Invasive Hemodynamic Assessment
Treatment groups
70 Participants
are divided into 1 treatment groupSponsors and collaborators
Nantes University Hospital
Lead sponsor
Fédération Française de Cardiologie
Collaborator
Source ClinicalTrials.gov