The goal of this protocol for an observational retrospective multi-site cohort study is to develop a predictive algorithm for suicidal behavior integrating genetic risk markers, digital phenotypes, and exposomic data in people with a lifetime history of suicide attempt. Participants will be aged from 12 onwards (requiring parental consent if under 18) and only be excluded if they are unable to provide a genetic sample or do not consent to the study. The main question\[s\] it aims to answer is:
\- Can genotyping/omics analysis of individuals with a history of suicidal behaviuor reveal potential genetic factors associated with suicide risk?
Secondary questions include:
1. Can behavioral factors associated with suicide risk be explored through data obtained from Google Takeout? 2. Is there an association between medication changes and suicidal behavior, as identified through the Unified Prescription Module and the Digital Health Record? 3. Do different suicidal phenotypes differ based on the collected variables? 4. Can the investigators construct an exposome using geolocated and time-stamped data from Google Takeout, combined anonymously with data from the National Statistics and Meteorology Institutes?
The investigators hypothesize that:
1. Individuals with a history of suicidal behavior will show significant genotypic differences compared to the general population (based on Spanish Genome Project data). 2. Suicidal phenotypes-especially between single and multiple attempters-will differ across collected variables, including genotype, omics, and exposome data.
participants will complete genetic assessments, digital phenotypes, clinical questionnaires and exposomic data
At least one suicide attempt in their lifetime.
The attempt must have occurred when the participant was older than 12 years old.
Participants must be at least 18 years old or have parental consent if aged 12-17.
medical contraindication prevents blood sample collection
unable to provide informed consent to participate in the study
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Lead sponsor
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz-ISCIII
Collaborator
Hospital Universitario Fundación Jiménez Díaz
Collaborator
Hospital Universitario Rey Juan Carlos
Collaborator
Hospitales Universitarios Virgen del Rocío
Collaborator
University of Seville
Collaborator
Universidad de Zaragoza
Collaborator
Universidad de Oviedo
Collaborator
Instituto de Investigación Sanitaria del Principado de Asturias - ISPA
Collaborator
Centro de Investigación Biomédica en Red de Salud Mental
Collaborator
Hospital Miguel Servet
Collaborator
Servicio de Salud del Principado de Asturias. Área Sanitaria III
Collaborator
Fundació d'investigació Sanitària de les Illes Balears
Collaborator
University of Castilla-La Mancha
Collaborator
Hospital del Mar Research Institute (IMIM)
Collaborator
Hospital de Aviles
Collaborator
Universitat Pompeu Fabra
Collaborator
University of Barcelona
Collaborator
Hospital Clinic of Barcelona
Collaborator
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.
Collaborator
Corporacion Parc Tauli
Collaborator
Universitat Autonoma de Barcelona
Collaborator
Institut de Recerca Biomèdica de Lleida
Collaborator
Hospital Clínico Universitario de Valencia
Collaborator
University of Valencia
Collaborator
Hospital Universitario La Fe
Collaborator
Hospital Provincial de Castellon
Collaborator
Universidad de Extremadura
Collaborator
University of Santiago de Compostela
Collaborator
Centre Hospitalier Universitaire de Nīmes
Collaborator
Centro de Investigación en Red de Enfermedades Raras (CIBERER)
Collaborator
Servicio Gallego de Salud
Collaborator
Universidad Autonoma de Madrid
Collaborator
Universidad Complutense de Madrid
Collaborator
Hospital Universitario La Paz
Collaborator
Centro de Biología Molecular Severo Ochoa, Spain (CBMSO)
Collaborator
Fundación General CSIC
Collaborator
Neuroscience Research Australia
Collaborator
The University of New South Wales
Collaborator
Hospital General Universitario Gregorio Marañon
Collaborator
Instituto de Investigación Sanitaria Gregorio Marañón
Collaborator
Universidad Carlos III de Madrid
Collaborator
Hospital San Carlos, Madrid
Collaborator
Hospital Universitario Ramon y Cajal
Collaborator
University of Alcala
Collaborator
Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Collaborator
Hospital Universitario de Móstoles
Collaborator
Universidad Rey Juan Carlos
Collaborator
Hospital Universitario Infanta Elena
Collaborator
Hospital Universitario 12 de Octubre
Collaborator
Fundación Instituto de Investigación Sanitaria de Navarra
Collaborator
Centro de Investigación Médica Aplicada (CIMA)
Collaborator
Hospital Universitario Araba
Collaborator
Bioaraba Health Research Institute
Collaborator
Euskal Herriko Universitatea - Universidad del País Vasco. Qualiker.
Collaborator
Universidad Católica del Maule
Collaborator