Prevention of Postoperative Respiratory Complications

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris

About this trial

Given the huge number of patients mechanically ventilated during general anaesthesia, optimizing alveolar recruitment by limiting pulmonary and systemic aggression is a key objective for further progress in perioperative patient management.

During general anaesthesia, ventilation disorders with atelectasis, derecruitment of posteroinferior zones and reduced functional residual capacity (FRC) occur in relation to the operative position, the effect of neuromuscular block and general anaesthesia. These conditions of poor pulmonary aeration favor postoperative respiratory complications and are responsible for excess mortality in the perioperative period.

Alveolar recruitment maneuvers (ARMs) are ventilatory strategies used during general anesthesia that aim to restore lung aeration with Positive End Expiratory Pressure (PEEP) sufficient to keep the lungs open afterwards. This pulmonary hyperinflation not only has a major impact on hemodynamics but also presents a risk of barotrauma. ARM is currently performed without precise measurement of the pressures prevailing in the lung.

Advanced monitoring is now available and integrated into the latest-generation ventilators and includes the combination of Transpulmonary pressure (TPP) and Electro-Impedance Tomography " (EIT) measurements.

The aim of this observational study is to measure and record advanced respiratory monitoring data in a minimally invasive way, during alveolar recruitment tests routinely performed for the target population (obese, prone, laparoscopic surgery). Describe and a posteriori analyze the recorded data and establish a relationship between the PEEP values set by conventional ARM and those determined by advanced monitoring combining EIT and PTP for the same patient.

Eligibility criteria

Qualifiers

Patients ≥ 18 years of age

scheduled surgery at Hospital Lariboisière.

scheduled to last more than 2 hours under general anesthesia for abdominal surgery under laparoscopy or surgery in the prone position, or for obese patients with a BMI >35.

And for whom the ventilator used includes advanced monitoring

Disqualifiers

- Patients under 18 years of age.

Contraindications to esophageal tube placement

Contraindications to ARMs

Patient opposed to protocol participation

Trial design

Treatments tested in this trial

  • Continuous measurement of esophageal pressure Peso (cmH2O)
  • Measurement of impedance variation with each respiratory cycle (EIT), Z in ohm
  • Measurement of regional respiratory compliance (EIT), Ohm/cmH2O
  • Measurement of lung volumes (EELV or CRF) mL, (ml/kg)
  • Continuous measurement of multiparametric monitoring data in place (hemodynamics, depth of sedation, respiratory data, temperature).
  • Quantification of delivered doses of hypnotics, morphine and paralytics
  • Demographic criteria: age, sex, height, weight, BMI, theoretical ideal weight, ASA. - Procedure-related criteria: type of surgery, technique (laparoscopic, endoscopic, laparoscopic), position, duratio

Treatment groups

No treatment groups listed

Sponsors and collaborators

Assistance Publique - Hôpitaux de Paris

Lead sponsor

M3DISIM

Collaborator

INSERM UMR-942, Paris, France

Collaborator