PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial

ConditionsBradyarrhythmia Atrioventricular Block Left Bundle Branch Area Pacing

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age19+

SponsorYonsei University

About this trial

PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period. The purpose of this study to compare the clinical outcomes of Left Bundle Branch Area Pacing (LBBAP) compared to Right Ventricular Pacing (RVP) in bradyarrhythmia patients who require high burden of ventricular pacing (\>40%).

Eligibility criteria

Qualifiers

At least 19 years old and willing and capable to give informed consent

Patients who is willing and able to comply with the prescribed follow-up tests and schedule of evaluations.

Disqualifiers

Incapacitated or unable to read or write

Patient who is an indication of ICD or CRT

History of prosthetic valve surgery on tricuspid valve

Prior myocardial infarction including ventricular septum

Trial design

Treatments tested in this trial

Left bundle branch area pacing
Right ventricular pacing

Treatment groups

450 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Yonsei University

Lead sponsor

Source ClinicalTrials.gov