Intestinal flora and metabolites are associated with multiple systemic diseases. Current approaches for acquiring information regarding microbiota/metabolites have limitations. We aimed to develop a precise sampling capsule endoscopy (SCE) for the convenient, non-invasive, and accurate acquisition of digestive bioinformation for disease diagnosis and evaluation. The SCE was used for sampling jejunum, ileum, and colon content in healthy volunteers. The GI liquid was then used for microbiome profiling and metabolomics profiling. In this study, we aimed to describe the characteristics and functions of key microflora in the whole intestinal microenvironment of healthy volunteers.
Male or female, age ≥18 years and ≤80 years;
American Society of Anesthesiologists (ASA) physical health risk level 1;
Good overall health, no clinically significant medical history;
No clinically significant signs were found in the physical examination;
Patients with digestive tract diseases such as cancer, inflammatory bowel disease, achalasia, esophageal diverticulum, etc.;
Patients who have participated in other clinical trials within three months or are currently participating in other clinical trials;
Patients currently use medication for other diseases or plan to use medication for treatment;
Patients who have used antibiotics within three months;