About this trial
Patients with iliofemoral vein thrombosis are prone to developing post-thrombotic syndrome (PTS). The profunda femoris vein (PFV) is an important inflow of the iliofemoral vein. Profunda femoris vein thrombosis clearance (PFV-TC) may improve the patency of iliofemoral vein and reduce the occurrence of PTS.
Eligibility criteria
Qualifiers
Age ≥ 18 years and ≤ 85 years;
Diagnosed with acute iliofemoral DVT involving iliac vein, common femoral vein, and PFV (confirmed by preoperative ultrasound, CT venography, or intraoperative venography);
Time from symptom onset to endovascular treatment ≤ 14 days;
Patient receives endovascular treatment with PMT;
Disqualifiers
Presence of pre-existing PTS in the limb scheduled for treatment, or a history of symptomatic DVT in the same limb within the past 2 years;
Concurrent symptomatic acute DVT involving the iliac vein and/or common femoral vein in the contralateral limb;
Known allergy to heparin, low-molecular-weight heparin, contrast media, or other relevant agents;
Concomitant severe pulmonary embolism with hemodynamic compromise, such as hypoxia or hypotension;
Trial design
Treatments tested in this trial
- Percutaneous mechanical thrombectomy with profunda femoris vein thrombosis clearance (PMT with PFV-TC)
- Percutaneous mechanical thrombectomy without profunda femoris vein thrombosis clearance (PMT without PFV-TC)
Treatment groups
Sponsors and collaborators
RenJi Hospital
Lead sponsor
Wenzhou Central Hospital
Collaborator
West China Hospital
Collaborator
Chengdu University of Traditional Chinese Medicine
Collaborator
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Collaborator
Changhai Hospital
Collaborator
First People's Hospital of Hangzhou
Collaborator