Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-99
SponsorFondazione del Piemonte per l'Oncologia

About this trial

This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.

Eligibility criteria

Qualifiers

Age ≥18 years

Written informed consent

Planned VATS upper or lower lobectomy for NSCLC

Minimally invasive thoracoscopic approach

Disqualifiers

Induction radiochemotherapy or chemo-immunotherapy

Severe COPD: GOLD 3 or higher

Sleeve resection or extended resection involving other lobes/chest wall/pericardium, etc.

Albumin intolerance/allergy

Trial design

Treatments tested in this trial

  • Progel Platinum
  • Mechanical Stapling

Treatment groups

160 Participants
are divided into 2 treatment groups