Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSied Kebir
About this trial
The study aims to investigate the prognostic significance of olfactory function in patients with glioblastoma. We are examining olfactory function at various points during therapy and correlating the results with survival data. In addition, neurocognitive tests will be carried out to correlate the results of olfactory function with the patient's cognitive abilities. Investigations into the quality of life and psychological condition of the patients are also performed. In addition to the cohort of glioblastoma patients, there is a control cohort without tumor disease in which the olfactory testing is also carried out in order to have a comparison.
Eligibility criteria
Qualifiers
At least 18 years of age
Newly-diagnosed glioblastoma (IDH wild-type)
Never received prior chemotherapy
Never received radiotherapy to the head or neck before
Disqualifiers
Presence of Neurodegenerative diseases (e.g. Parkinson's disease, Alzheimer's disease, Huntington's disease, Korsakoff's syndrome, Pick's disease, Shy-Drager syndrome)
History of invasive tumors or surgery in the head or neck area, except for surgeries for non-invasive skin tumors (e.g. basal cell carcinomas)
Permanent olfactory impairment following infections (e.g., influenza, coronavirus)
Conditions that, in the examiner's judgment, could interfere with the participant's study compliance (e.g., schizophrenia)
Trial design
Treatments tested in this trial
- olfactory testing (threshold and identification test)
Treatment groups
128 Participants
are divided into 2 treatment groupsSponsors and collaborators
Sied Kebir
Lead sponsor
University Hospital, Essen
Sponsor institution
Münster University Hospital, Germany
Collaborator
Source ClinicalTrials.gov