This prospective observational study aims to determine whether specific parameters measured by transcranial Doppler ultrasound (TCD) can predict clinical outcomes in patients with acute ischemic stroke (AIS). The primary objective is to evaluate the association between middle cerebral artery (MCA) flow velocities and short-term neurological improvement. Secondary outcomes include the presence of collateral flow and flow patterns in relation to functional recovery measured by NIHSS and modified Rankin Scale (mRS) scores.
Age ≥ 18 years
Clinical diagnosis of acute ischemic stroke
Onset of symptoms ≤ 24 hours before admission
Underwent or will undergo transcranial Doppler ultrasound within 24 hours of symptom onset
Evidence of intracerebral hemorrhage on imaging
Inadequate temporal acoustic window for transcranial Doppler
Intubated or hemodynamically unstable prior to Doppler evaluation
Known diagnosis of neurodegenerative disease significantly affecting baseline neurological function (e.g., advanced dementia, Parkinson's disease)
Jose Ivan Rodriguez de Molina Serrano
Lead sponsor
Clinica Mexico
Sponsor institution