PRogression of Atheroma Evaluated by CT Angiography and IntraCoronary Imaging tEchniques
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRuijin Hospital
About this trial
This is a combined cohort study with retrospectively and prospectively enrolled coronary artery disease (CAD) patients. All the patients will undergo clinical follow-up for up to 5 years, and repeat coronary CTA will be conducted after 2 years. Comprehensive morphological and functional plaque analysis will be performed. The impact of these morphological and functional parameters, alongside cardiometabolic factors and pharmacological treatments on plaque progression and the occurrence of major adverse cardiovascular events (MACEs) will be analyzed. In addition, intracoronary imaging techniques will be used to improve the accuracy of plaque analysis by coronary CTA.
Eligibility criteria
Qualifiers
Age ≥ 18 years
Clinically significant angina pectoris, or suspected CAD
Receive coronary CTA scan, with a visible plaque (defined as ≥25% diameter stenosis) in major coronary arteries.
Disqualifiers
Unsuitable for coronary CTA (such as severe renal impairment, uncontrolled thyroid condition, allergic to iodine, etc.)
Receive percutaneous coronary intervention (PCI) within 6 months
Prior history of myocardial infarction or heart failure
Prior history of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG)
Trial design
Treatments tested in this trial
- Not listed
Trial groups
50,000 Participants
are grouped into 1 trial groupSponsors and collaborators
Source ClinicalTrials.gov