To analyse the efficacy of different preoperative prophylactic antimicrobial regimens for perioperative infection prevention in patients undergoing hepatobiliary surgery in a high antimicrobial resistance setting.
Adult patients aged ≥18 years;
Deemed eligible for elective hepatobiliary surgery;
Demonstrated comprehension of the study nature and expressed willingness to comply with trial procedures;
Capable of providing written informed consent.
History of β-lactam allergy or hypersensitivity
Uncontrolled preoperative infection;
Current or recent (within the preceding month) systemic corticosteroid administration;
Severe hepatic or renal impairment;