The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel.
The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans?
Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar.
Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.
Any type of resection for adenomas larger than 20 mm in size (endoscopically evaluated) or endoscopically resected T1 cancers.
Acceptance of the treatment and follow-up program.
Capability to understand and follow the instructions.
Patients allocated to "high-risk" group because of many small polyps (>4).
Pregnancy.
Known relevant allergies.
Chronic consumption of COX (cyclooxygenase) inhibitors (Aspirin, Celecoxib, Ibuprofen, Diclofenac, Ketoprofen, Ketorolac, Indometacin, Naproxen, Piroxicam) or immunosuppressive agents (Methotrexate, Azathioprine or glucocorticoids).
Odense University Hospital
Lead sponsor
Karolinska Institutet
Collaborator
Umeå University
Collaborator
Uppsala University Hospital
Collaborator
Svendborg Hospital
Collaborator
Ersta Hospital, Sweden
Collaborator
St Goran's Hospital
Collaborator
Sahlgrenska University Hospital
Collaborator