This is a single-center prospective, non-randomized controlled clinical study in China using CliniMACS TCRα/β+ cell depleted stem cell haploidentical donors versus conventional Beijing protocol for haploidentical hematopoietic stem cell transplantation in children.
Age 8 weeks to 18 years
Children who meet the indicators haploidentical hematopoietic cell transplantation
No HLA ≥ 9/10 donor or not suitable for this type of donor due to illness
Informed consent must be signed (by the patient or legal representative)
Liver function abnormalities with bilirubin >2 mg/dL and elevation of transaminases higher than 400 U/L
Chronic active viral hepatitis
Ejection fraction <50%
Respiratory failure necessitating supplemental oxygen
Sijia Gu
Lead sponsor
Shanghai Jiao Tong University School of Medicine
Sponsor institution