This study corresponds to a monocentric prospective cohort of adult patients with systemic sclerosis.
It will allow the constitution of an organized collection of longitudinal clinical data as well as collection of biological samples, including blood samples, as well as stool sample and skin swab for microbiota analysis.
Major patient with systemic sclerosis defined according to the EULAR 2013 criteria (see Appendix 1)
Patient evaluated within the framework of the reference center for rare autoimmune diseases of the CHU of Brest.
Patient affiliated to the social security system
Patient having signed a written informed consent.
Minor
Patient under legal protection (guardianship, curatorship)
Refusal to participate
Patient unable to consent