Investigating the Relationship Between Oral Microbiome Alterations and Tumor Markers in Locally Advanced Oral Squamous Cell Carcinoma (LA-OSCC) After Neoadjuvant Chemoimmunotherapy: Implications for Therapeutic Efficacy, Chemoresistance, and Prognostic Assessment
Oral squamous cell carcinoma (OSCC) diagnosed as locally advanced (T3N0M0, T1-3N1M0, T4aN0-2M0, T1-4aN3M0, or T4bN0-3M0) according to AJCC staging criteria.
Their age ranged from 18 to 80 years;regardless of gender.
Absence of prior head and neck radiation therapy or chemotherapy.
Adequate blood function: white blood cell count (WBC) >＝3.5×10^9/L, platelet count (PLT) >＝75×10^9/L：Hemoglobin concentration (HGB) >＝90g/L.
Pregnancy or lactation (for female participants).
Patients with a history of epilepsy or psychiatric disorders that were not well-controlled.
Patients with severe allergic diathesis or suspected or confirmed alcohol or drug addiction.
Patients who had taken antibiotics within 7 days before enrollment.