Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or HR T1aN0M0 EAC).
Patients with submucosal or high-risk mucosal EAC diagnosed in an ER specimen, by an expert gastrointestinal (GI) pathologists.
Signed informed consent.
Prior history of high-risk mucosal or ≥T1sm.
Synchronous esophageal squamous cell carcinoma.
Suspicion on lymph node metastasis or distant metastasis on EUS, ultrasound of the neck or CT-thorax-abdomen performed six weeks after ER during baseline measurement.
Tumor-positive deep resection margin (R1) in ER specimen.
Amsterdam UMC
Lead sponsor
Amsterdam UMC, location VUmc
Sponsor institution