This is a population-based prospective cohort study, aiming to assess the prevalence, distributional characteristics, and dynamic change of cerebral small vessel dysfunction in a Chinese community population using advanced vascular imaging techniques; meanwhile to investigate the effect of vascular risk factors on cerebral small vessel dysfunction, cardiovascular and cerebrovascular diseases, cognitive dysfunction, and mortality.
Community-dwelling adults aged 50-75 years;
Registered Beijing household residents or residents who can be followed up stably in their own communities for a long period;
Subjects with written informed consents.
Residents with moderate to severe disabilities (MRS ≥3), mental illness, stroke, dementia, and other serious neurological disorders (e.g., encephalitis, Parkinson's disease, epilepsy, brain tumors, and rare genetic diseases of the nervous system);
Life expectancy of ≤4 years due to serious diseases such as end-stage cancer;
Contraindications to magnetic resonance imaging such as implanted devices (e.g., pacemakers, defibrillators, and others);
Residents who are participating in other studies.
Beijing Tiantan Hospital
Lead sponsor
Beijing Daxing District People Hospital
Collaborator