Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training

ConditionStroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-80
SponsorMcGill University

About this trial

The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these patients. Although physical exercise is usually recommended after stroke, there is very little information about the protective effect of exercise implemented in early stages of recovery as a potential protective measure against cognitive decline and dementia risk in these patients. This study will investigate the effect of a multimodal exercise intervention implemented early after the stroke event on cognition and on a selected group of markers that can predict cognitive decline and dementia risk.

Eligibility criteria

Qualifiers

have had a first-ever ischemic/hemorrhagic stroke confirmed by MRI/CT 0-6 months prior to participation.

Able to independently walk at least 10 meters (assistive devices permitted) and capable of following instructions will be required.

Disqualifiers

Diagnosed with dementia

Medications that impact cognition

Absolute contraindications to exercise or MRI scanning

Significant disability (modified Rankin score >3)

Trial design

Treatments tested in this trial

  • Multimodal Training
  • Balance, Toning and Stretching

Treatment groups

120 Participants
are divided into 2 treatment groups

Sponsors and collaborators

McGill University

Lead sponsor

Jewish Rehabilitation Hospital

Collaborator

McMaster University

Collaborator

Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal

Collaborator

Montreal Neurological Institute and Hospital

Collaborator