Pulsed Field Ablation Versus Radiofrequency Ablation for Persistent Atrial Fibrillation
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorBeijing Anzhen Hospital
About this trial
This clinical trial aims to compare the efficacy and safety of pulsed field ablation and radiofrequency ablation to treat persistent atrial fibrillation in adults.
Participants will:
Undergo pulsed field ablation or radiofrequency ablation. Keep follow-up for at least 12 months.
Eligibility criteria
Qualifiers
18-80 years
Patients with non-valvular persistent atrial fibrillation undergoing their first catheter ablation (AF duration: 3 months to 3 years)
Left atrial diameter on parasternal long-axis view of echocardiogram < 50 mm
Agree to be randomly assigned to the ablation strategy and able to follow up
Disqualifiers
Atrial fibrillation due to reversible causes
LVEF < 30%
Severe congenital heart disease
Severe liver or kidney dysfunction (eGFR < 15, Child-Pugh grade 3), or history of dialysis
Trial design
Treatments tested in this trial
- Pulsed Field Ablation
- Radiofrequency Ablation
Treatment groups
700 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov