Quantification & Classification of Inflammatory Cells in Uveitis Using OCT

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age5-85
SponsorOregon Health and Science University

About this trial

The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.

Eligibility criteria

Qualifiers

Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.

Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).

Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.

Disqualifiers

Inability to give informed consent.

Inability to maintain stable fixation for OCT imaging.

Inability to commit to required visits to complete the study.

Pregnancy and breastfeeding.

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

125 Participants
are grouped into 3 trial groups

Sponsors and collaborators

Oregon Health and Science University

Lead sponsor

National Eye Institute (NEI)

Collaborator