In this clinical study vascular dynamics in the neonatal brain and kidney will be monitored by CUES and ULM before, during and after hypothermia treatment in neonates with asphyxia.
Fulfillment of the inclusion criteria for hypothermia treatment according to the AWMF guideline
Severe acidosis (pH ≤7.0 or a base deficit ≥16 mmol/l) in umbilical cord blood or a blood sample from the first hour of life, and
clinical signs of moderate or severe encephalopathy (severity grade 2 or 3 according to Sarnat & Sarnat), and
postnatal age ≤6h, and
Lack of consent of at least one parent
Pre-existing brain malformations
Absence of the competent examiner