The goal of this study is to evaluate whether 4D MRI provides a better assessment of mitral regurgitation quantification and associated ventricular remodeling than standard imaging techniques: echocardiography and 2D MRI, in patients suffuring from mitral regurgitation. 4D MRI demonstrated its superiority to 2D MRI in some other valve diseases but remains not widely used, due to a lack of evidence. The main question our study aims to answer is:
• Is mitral regurgitant volume measured on 4D MRI more strongly related to remodeling progression (after correction of regurgitation or not) than regurgitant volume measured on 2D MRI and echocardiography?
Participants will undergo 4D MRI, 2D MRI and echocardiography twice at six-month intervals.
from 18 to 85 years old
having signed a consent form to participate in the study
suffering from mild, moderate or severe mitral regurgitation based on an ultrasound graduation
able to undergo echocardiography and IRM within 7 days after recruitment and then at 6 months
suffering from aortic regurgitation or stenosis or mitral stenosis associated with more than moderate MR, intracardiac shunting or hypertrophic cardiomyopathy
suffering from secondary MR
having a contraindication to gadolinium-based contrast agent
having a pacemaker, defibrillator or any other contraindication to MRI
Assistance Publique - Hôpitaux de Paris
Lead sponsor
Ministry of Health, France
Collaborator
GIRCI IDF
Collaborator