Health TrialsbyHealthPanel

Quantifying Blood Flow in the Aorta

ConditionHealthy Aortic Blood Flow
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-85
SponsorUniversity of Twente

About this trial

This study aims to gain insights into aortic blood flow in healthy volunteers using PC 4D-flow MRI

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy (in particular without any cardiovascular disease or history thereof) men or women

18 years of age or above;

BMI ≤ 30;

Willingness to undergo MRI scans;

Disqualifiers

Irregular heartbeat.;

Any history of cardiovascular disease or current cardiovascular disease;

The standard MRI exclusion criteria (such as pacemakers, cerebral vascular clips, pregnancy, claustrophobia)

Trial population

Healthy subjects with no known cardiovascular disease or history thereof

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • 4D-flow Magnetic Resonance Imaging

    Other intervention

    Subjects will undergo MRI scans of the thorax and abdomen from which we will derive aortic blood flow velocity fields. This intervention will be performed in the same manner on all groups.

  • Questionnaires

    Other intervention

    Subjects fill in a questionnaire regarding their weight, height, age and gender. They also fill in a safety check form to test if MRI can be applied safely.

Treatment groups

70 Participants
are divided into 7 treatment groups

7

Treatment groups

See each treatment group below.

Group A: Group 12 interventions
Group B: Group 22 interventions
Group C: Group 32 interventions
Group D: Group 42 interventions
Group E: Group 52 interventions
Group F: Group 62 interventions
Group G: Group 72 interventions

Trial outcomes

Primary outcomes

1

Aortic blood flow velocity fields

Velocity fields will be acquired, consisting of vectors that describe the velocity magnitude (cm/s) and direction (dimensionless) of blood flow in the aorta. For visualisation purposes, arrows will be used to overlay the shape of the volunteers aorta. Colours of the arrrows indicate the velocity magnitude and direction of the arrows inicate the direction of flow. Velocity fields are generated for the the full aorta, from the ascending aorta to internal/external iliac arteries, including branched arteries such as subclavian arteries, common carotid artery, and visceral branch vessels.

Time frame
Day 1

Secondary outcomes

1

Age of volunteer

Age of volunteer (in years) for division into groups based on gender and age, gathered using a questionnaire.

Time frame
Day 1
2

Gender of volunteer

Gender of volunteer (male/female/other) for division into groups based on gender and age, gathered using a questionnaire.

Time frame
Day 1
3

Height of volunteer

Height (in m) for BMI (in kg/m\^2) calculation, gathered using a questionnaire.

Time frame
Day 1
4

Weight of volunteer

Weight (in kg) for BMI (in kg/m\^2) calculation, gathered using a questionnaire.

Time frame
Day 1

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Twente

Lead sponsor

Source ClinicalTrials.gov
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