This multicenter prospective study aims to evaluate the correlation between quantitative ultrasound fat fraction (USFF) and MRI-PDFF (Proton Density Fat Fraction) for liver fat quantification in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The study will compare the diagnostic accuracy of quantitative ultrasound imaging against MRI-PDFF as the reference standard.
Patients with clinically suspected MASLD based on abnormal ultrasound or liver function tests requiring liver ultrasound or MRI examination
BMI ≥25 kg/m² or waist circumference >90 cm (male) or >80 cm (female), suggesting high likelihood of fatty liver disease
Living liver transplant donors requiring preoperative liver ultrasound or MRI examination
Age ≥18 years
History of esophageal varices, ascites, hepatic encephalopathy, or acute biliary obstruction
History of liver cancer diagnosis or treatment
History of liver surgery
Pregnancy
Single group
Quantitative ultrasound (DeepUSFF)
Device\*\*Novel Quantitative Ultrasound Technology Assessment\*\* This study evaluates Samsung Medison's proprietary DeepUSFF (Deep Learning-based Ultrasound Fat Fraction) technology, a next-generation quantitative ultrasound method for liver fat assessment that differs from conventional ultrasound approaches in several key aspects: advanced RF data analysis, proprietary technology, standardized protocol, direct MRI-PDFF correlation, specific MSALD poopulation and multicenter design.
Correlation between Ultrasound Fat Fraction and MRI-PDFF
earson correlation coefficient between quantitative ultrasound fat fraction (USFF) and MRI-PDFF
Correlation between Ultrasound Fat Fraction and MRI-PDFF
Measure: Pearson correlation coefficient between quantitative ultrasound fat fraction (USFF) and MRI-PDFF
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Seoul National University Hospital
Lead sponsor
Northeastern Ohio Radiology Research and Education Fund
Collaborator
