This multicenter prospective study aims to evaluate the correlation between quantitative ultrasound fat fraction (USFF) and MRI-PDFF (Proton Density Fat Fraction) for liver fat quantification in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The study will compare the diagnostic accuracy of quantitative ultrasound imaging against MRI-PDFF as the reference standard.
Patients with clinically suspected MASLD based on abnormal ultrasound or liver function tests requiring liver ultrasound or MRI examination
BMI ≥25 kg/m² or waist circumference >90 cm (male) or >80 cm (female), suggesting high likelihood of fatty liver disease
Living liver transplant donors requiring preoperative liver ultrasound or MRI examination
Age ≥18 years
History of esophageal varices, ascites, hepatic encephalopathy, or acute biliary obstruction
History of liver cancer diagnosis or treatment
History of liver surgery
Pregnancy
Seoul National University Hospital
Lead sponsor
Northeastern Ohio Radiology Research and Education Fund
Collaborator