With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.
Between 8 and 21 years of age, inclusive
Newly diagnosed primary brain tumor of any location and any histology that will be treated with proton radiation therapy
Life expectancy of at least one year
Able to understand and willing to consent or assent to the research proposed (or that of a legally authorized representative, if applicable), along with consent of legal guardian(s) if applicable
Presence of visual impairment to an extent that the patient is unable to complete the computer testing
Contraindication to MRI scan (i.e. due to cardiac pacemaker)
Presence of programmable shunt or dental braces
Requires sedation for MRI scans
Washington University School of Medicine
Lead sponsor
United States Department of Defense
Collaborator
The Foundation for Barnes-Jewish Hospital
Collaborator
Children's Cancer Research Fund
Collaborator