Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release
ConditionDupuytren Contracture
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45+
SponsorDartmouth-Hitchcock Medical Center
About this trial
The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are:
• Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum?
Participants will undergo:
* Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy
Eligibility criteria
Qualifiers
Age 45 or greater with DC
Extension deficit >10 degrees
Unable to simultaneously place the affected finger and palm flat on a table.
Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
Disqualifiers
Unsuccessful non-surgical release (> N/1 disease)
They develop an open wound during CCH
Breast feeding or pregnancy
A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
Trial design
Treatments tested in this trial
- Radiation therapy
Treatment groups
95 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov