Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorWestern Sydney Local Health District
About this trial
The goal of this randomized clinical trial is to test the efficacy of stereotactic body radiation therapy (SBRT) in treating ventricular tachycardia (VT) in patients with advanced structural heart disease. The main questions it aims to answer are:
* What is the efficacy of SBRT compared to catheter ablation (CA) in achieving a ≥ 75% reduction in VT burden at 6 months * What is the comparable safety profile of SBRT vs CA Researchers will compare SBRT and CA (standard of care).
Eligibility criteria
Qualifiers
Structural heart disease (including ischaemic cardiomyopathy , non-ischaemic cardiomyopathy or congenital heart disease and defined as any one of
segmental or global decreased ventricular wall motion as defined by TTE, CT or cMRI
myocardial hypertrophy
myocardial scar (evidenced by late gadolinium enhancement on cMRI, wall thinning on cardiac CT, low voltage on electrophysiological study or abnormal intracardiac echocardiography)
Disqualifiers
Age < 18 years
Life expectancy < 3 months
Catheter ablation deemed futile or with prohibitive risk by cardiac electrophysiologist.
Unwilling or unable to provide consent
Trial design
Treatments tested in this trial
- SBRT
- CA
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Western Sydney Local Health District
Lead sponsor
University of Sydney
Collaborator
National Heart Foundation, Australia
Collaborator
Source ClinicalTrials.gov