Every year there are an estimated 230,000 childhood deaths from TB. There is an urgent need for novel tests for TB diagnosis in children under 15 years. The Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and the Assessing Diagnostics at Point-of-care for Tuberculosis in children (ADAPT for Kids) studies seek to reduce the burden of TB worldwide by evaluating faster, simpler, and less expensive TB triage and diagnostic tests for use in children.
Unexplained cough for any duration
TB contact or tuberculin skin test or interferon gamma release assay positive
Abnormal chest X-ray (any abnormality) OR
Unexplained weight loss OR unexplained failure to thrive OR Severe Acute Malnutrition
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University of California, San Francisco
Lead sponsor
Instituto Nacional de Saúde, Mozambique
Collaborator
National Referral Hospital
Collaborator
University of Cape Town
Collaborator
Johns Hopkins University
Collaborator
Elizabeth Glaser Pediatric AIDS Foundation
Collaborator
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborator
University of California, Irvine
Collaborator