Real Life Study of Biologicals in Patients With Severe CRSwNP
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorUniversity Hospital, Ghent
About this trial
This study is a pragmatic, real-life, observational study recruiting adult patients with chronic rhinosinusitis with nasal polyposis who are eligible to start biologicals as standard treatment. The aim of this study is to observe the long-term outcomes of biologicals in CRSwNP patients with or without comorbid asthma in 'real life'. Moreover, the investigators will gain insight into the mechanisms of biologicals in the local and systemic immunity of these patients and investigate novel local and systemic biomarkers and predictors of response.
Eligibility criteria
Qualifiers
Signed informed consent form (ICF),
Age between 18 and 80 years at time of signing ICF,
Able to comply with the study protocol, in the investigator's judgment,
In group one: patients with severe allergic and/or eosinophilic asthma, defined by being currently treated with a biological (SoC) OR starting treatment with a biological (SoC).
Disqualifiers
None
Trial design
Treatments tested in this trial
- Mepolizumab
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov