This study has two phases:
Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers.
Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers
Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink
Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).
Subjects who can speak and understand English.
a history of diabetes, cardiovascular disease, liver, or renal disease
current or history of smoking and illicit drug use
blood pressure ≥160/100 mm Hg
other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol>230 mg/dl and/or LDL cholesterol>160 mg/dl)
The University of Texas at Arlington
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborator