Reducing Heart Failure Risk in Late-Life With Physical Activity

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorBrigham and Women's Hospital

About this trial

The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise.

The main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program.

The trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study:

* Cardiopulmonary exercise test (CPET) * Echocardiogram * Physical function test * 6-minute walk test * Hand grip strength * Quality of life questionnaire * Blood draws

Researchers will compare results between those who do and don't participate in the exercise program.

Eligibility criteria

Qualifiers

Hypertension (controlled on stable medication regimen)

Structural heart abnormality (LVH or LA enlargement)

LVEF > 50%

Sedentary

Disqualifiers

Diabetes

Unable to exercise

Supplemental oxygen use

Pulmonary hypertension

Trial design

Treatments tested in this trial

  • Cardiac Rehabilitation
  • Attention Control

Treatment groups

42 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators