Reducing Pain in Complex Regional Pain Syndrome Using Personalized Brain Stimulation: A Feasibility Study

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorMcMaster University

About this trial

This research study looks at the feasibility of using a new treatment, noninvasively activating the brain through repetitive transcranial magnetic stimulation (rTMS) to treat pain symptoms of complex regional pain syndrome (CRPS). This study will help us determine if this technique is feasible (able to recruit participants and if the research activities are feasible and can be used to treat CRPS patients with pain in a larger study. The investigators will also examine how TMS can be personalized to individuals using an individual's brain activity measured using EEG. The investigators will also study whether the effects of TMS are stronger if the TMS is delivered during a specific timing of the EEG activity.

Eligibility criteria

Qualifiers

Diagnosis of CRPS Type 1 affecting the upper or lower limb using the revised Budapest criteria

History of CRPS of at least 3 months since the start of symptoms or diagnosis

Disqualifiers

CRPS diagnosis greater than 3 years to avoid patients with chronic CRPS who may not respond to interventions

Contraindications to transcranial magnetic stimulation (TMS)

Known psychological diagnosis affecting comprehension

Prior experience with TMS

Trial design

Treatments tested in this trial

  • Repetitive transcranial magnetic stimulation

Treatment groups

10 Participants
are divided into 1 treatment group

Sponsors and collaborators

McMaster University

Lead sponsor

Michael G. DeGroote Institute for Pain Research and Care (IPRC)

Collaborator