Reducing Respiratory Virus Transmission in Bangladeshi Classrooms
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age9-12
SponsorStanford University
About this trial
This study will test if affordable air cleaning devices (box fans with a filter attached and/or ultraviolet light lamps) installed in classrooms can reduce the number of viral respiratory illnesses schoolchildren experience.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Schoolchildren of Bangladesh Government-run primary schools in Dhaka, Bangladesh ages 9 - 12 years, of all gender identifiers (male, female, transgender, prefer not to designate), without specific ethnic selection amongst standard school children of Bangladesh government schools in Dhaka, Bangladesh.
Disqualifiers
School children of non-Bangladesh Government-run primary schools and/or schoolchildren who do not attend a Bangladesh Government-run primary school in Dhaka, Bangladesh.
School children who are not able to or have a contraindication with the ability to comply with study procedures.
Trial design
Design model
Parallel
Treatments tested in this trial
Box Fan
DeviceClassrooms assigned to this arm will be equipped with 2 - 8 box fans each with a single minimum efficiency reporting value-14 (MERV-14) filter sufficient to increase effective air changes per hour to 12 based on the clean air delivery rate measured in cubic feet per minute of the box fan + filter \* 60 divided by the room volume.
UV Germicidal Irradiation Lamp Unit
DeviceClassrooms assigned to this arm will be equipped with one or two 222nm wavelength light ultraviolet germicidal irradiation lamp units (number of units per classroom based on room volume).
Combined: Box Fan and UV Germicidal Irradiation Lamp Units
DeviceClassrooms assigned to this arm will be equipped with both box fans and UV germicidal irradiation lamp units.
Treatment groups
20,000 Participants
are divided into 4 treatment groupsGroup A: Box FanExperimental treatment 1 intervention
Group B: UV Germicidal Irradiation Lamp UnitExperimental treatment 1 intervention
Group C: Combined: Box Fan and UV Germicidal Irradiation Lamp UnitsExperimental treatment 1 intervention
Group D: Non-Interventional ControlNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Total number of symptomatic respiratory illness episodes due to either Influenza or SARS- CoV-2
Study personnel will visit each school twice weekly. They will identify any students within the study classrooms who were absent or who have symptoms consistent with the World Health Organization (WHO) definition of influenza like illness. For children who were absent or who have symptoms, study personnel will visit the child's home, and if the student's parent provides informed consent, collect more detailed information on signs and symptoms, and a throat swab from the child. The throat swab will be placed on viral transport media, placed on ice and transported to the One Health Laboratory at the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b). One aliquot from the specimen will be analyzed for Influenza A, Influenza B, and SARS-CoV-2. In the laboratory, nucleic acid in the throat swab specimen will be extracted and one-step real-time (RT)-PCR conducted to assess the presence of RNA from Influenza A, Influenza B or SARS-CoV-2.
Time frame
Over 40 weeks of observationSecondary outcomes
1
Total number of symptomatic influenza-like illness episodes
Study personnel will visit each school twice weekly. They will identify any students within the study classrooms who were absent or who have symptoms consistent with the WHO definition of influenza like illness.
Time frame
Over 40 weeks of observation2
Total number of symptomatic influenza episodes
Study personnel will visit each school twice weekly. They will identify any students within the study classrooms who were absent or who have symptoms consistent with the WHO definition of influenza like illness. For children who were absent or who have symptoms, study personnel will visit the child's home, and if the student's parent provides informed consent, collect more detailed information on signs and symptoms, and a throat swab from the child. The throat swab will be placed on viral transport media, placed on ice and transported to the One Health Laboratory at icddr,b. One aliquot from the specimen will be analyzed for Influenza A or Influenza B. In the laboratory, nucleic acid in the throat swab specimen will be extracted and one-step real-time RT-PCR conducted to assess the presence of RNA from Influenza A or Influenza B.
Time frame
Over 40 weeks of observation3
Total number of symptomatic SARS-CoV2 episodes
Study personnel will visit each school twice weekly. They will identify any students within the study classrooms who were absent or who have symptoms consistent with the WHO definition of influenza like illness. For children who were absent or who have symptoms, study personnel will visit the child's home, and if the student's parent provides informed consent, collect more detailed information on signs and symptoms, and a throat swab from the child. The throat swab will be placed on viral transport media, placed on ice and transported to the One Health Laboratory at icddr,b. One aliquot from the specimen will be analyzed for SARS-CoV2. In the laboratory, nucleic acid in the throat swab specimen will be extracted and one-step real-time RT-PCR conducted to assess the presence of RNA from SARS-CoV2.
Time frame
Over 40 weeks of observation4
Total number of student absentee episodes
Study personnel will visit each school twice weekly. They will identify any students within the study classrooms who were absent.
Time frame
Over 40 weeks of observationLocations
Sponsors and contacts
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Stanford University
Lead sponsor
International Centre for Diarrhoeal Disease Research, Bangladesh
Collaborator
Source ClinicalTrials.gov
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