Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18+
SponsorMedical College of Wisconsin

About this trial

The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.

Eligibility criteria

Qualifiers

Hypertensive disorders of pregnancy (HDP) diagnosis, specifically gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines

Postpartum day 0-4

Age ≥ 18 years

Able to communicate in English or in Spanish

Disqualifiers

Pre-gestational hypertension

Type 1 or type 2 diabetes mellitus

Admitted to intensive care unit at the time of screening

Diagnosed with HDP during postpartum readmission after discharge from delivery hospitalization

Trial design

Treatments tested in this trial

  • Nifedipine ER

Treatment groups

618 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Medical College of Wisconsin

Lead sponsor

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator