The main goal of the study is to abandon breast surgery in patients with breast cancer with a clinical complete response (cCR) after neoadjuvant systemic therapy and confirmed pCR using Vacuum-assisted biopsy (VAB) and sentinel lymph node biopsy (SLNB).
Evidence of the high diagnostic accuracy (sensitivity and specificity) of vacuum aspiration biopsy in determining pCR in patients with clinical complete response after neoadjuvant systemic therapy will allow abandoning breast surgery in favor of radiation therapy alone, improving the quality of life of these patients.
age> 18 years.
morphologically confirmed diagnosis of breast cancer, IIA-IIIA stage
ECOG score 0-1.
life expectancy of more than 3 months.
Inconsistency with inclusion criteria.
Conducting earlier any systemic therapy for breast cancer.
stage 4 cancer
carrier mutations of the BRCA1 / 2 gene