Regional Anesthesia Techniques in Breast Surgery

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18+
SponsorXiaguang Duan

About this trial

This clinical trial aims to evaluate the efficacy of liposomal bupivacaine and ropivacaine, when administered via paravertebral block, the rhomboid intercostal and subserratus plane (RISS) block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block, in patients undergoing breast surgery (including augmentation, fibroadenoma excision, and mastectomy). The primary objectives are to determine:

1. Whether the use of liposomal bupivacaine or ropivacaine reduces the postoperative analgesic requirements in participants. 2. What potential adverse events participants experience when using liposomal bupivacaine or ropivacaine. 3. Which of the following regional anesthesia techniques provides superior analgesia: paravertebral block, RISS block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block.

Participants will undergo one of the following regional anesthesia techniques upon arrival to the surgical suite: paravertebral block, RISS block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block. Following regional anesthesia administration, general anesthesia with endotracheal intubation will be performed. Participants' vital signs, postoperative analgesic consumption, and recovery will be recorded.

Eligibility criteria

Qualifiers

American Society of Anesthesiologists (ASA) physical status classification I-III.

Age of 18 years or older.

Scheduled to undergo breast surgery, including augmentation, fibroadenoma excision, or mastectomy.

Disqualifiers

Known allergy to local anesthetics.

Pregnancy or lactation.

Coagulation disorders.

Severe cardiopulmonary disease.

Trial design

Treatments tested in this trial

  • General Anesthesia (GA)
  • Paravertebral Block (PVB)
  • Rhomboid Intercostal and Subserratus Plane Block (RISS)
  • Pectoral Nerves Block II (PECS II)
  • Intercostal Nerve Block (INB)
  • Serratus Anterior Plane Block (SAPB)
  • Epidural Block

Treatment groups

180 Participants
are divided into 6 treatment groups

6

Treatment groups

See each treatment group below.

Sponsors and collaborators

Xiaguang Duan

Lead sponsor

Inner Mongolia Baogang Hospital

Sponsor institution