Regional Phenotyping of CF and Non-CF Bronchiectasis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age5-100
SponsorChildren's Hospital Medical Center, Cincinnati
About this trial
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.
Eligibility criteria
Qualifiers
CF Patients: Diagnosis of CF based on sweat chloride >60 mMol/l
Presence of two disease causing CFTR mutations, or end organ manifestations of disease.
Age minimum 5 years.
Care provided by the CCHMC CF Care Center or other regional CF Care Centers if required to achieve recruitment goals.
Disqualifiers
Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
Pregnancy or lactation.
Subjects 5 years of age and older with no known history of cardiopulmonary disease.
Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
Trial design
Treatments tested in this trial
- Xenon
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov