Relation Between Psychoactive Drugs Overdosage and Severity of Falls in Elderly People
ConditionFall
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age75+
SponsorUniversity Hospital, Caen
About this trial
There are many epidemiological data on the relationship between the number or nature of psychoactive medications used and the risk of falling in elderly, but very little on the relationship between the amount of psychoactive medication actually present in the blood and the severity of the fall. However, the inevitable drug-drug interactions related to polypharmacy and the pharmacokinetic modifications related to old age may lead plasma overdose situations which can potentiate the risk of falls but also aggravate these consequences. The investigators therefore propose a study with the objective of verifying whether the proportion of falls with serious traumatic consequences is more frequent in patients over 75 years old, presenting plasma overdoses of psychoactive drugs (plasma concentrations higher than the usual therapeutic concentrations) in regard to those between therapeutic ranges.
The aim of this work is to verify if the falls present more severe characters when the psychoactive drug concentrations are beyond the usual therapeutic ranges.
Eligibility criteria
Qualifiers
Patient (male, female) aged 75 and over admitted to the emergency room for a fall and for whom hospitalization (in geriatrics or not) after going to the emergency room is planned
Patient consuming at least one psychoactive drug from the list provided in the protocol
Patient able to move before hospitalization with or without technical assistance
Patient who signed the consent
Disqualifiers
Patient not requiring hospitalization after going to the emergency room
Patient having fallen for more than 12 hours before inclusion in the study (time of sampling) [risk of excessive elimination of certain drugs with short half-lives]
Parkinsonian patient or patient who has fallen following a convulsive attack
Patient with a life-threatening prognosis in the very short term (state of shock, palliative care planned from the emergency room)
Trial design
Treatments tested in this trial
- Blood sampling for psychoactive drugs dosage
Treatment groups
400 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov