Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-99
SponsorUniversity Hospital, Angers

About this trial

The main objective is to assess the effect of increased PEEP on echo-Doppler venous congestion in ARDS patients at two PEEP levels, by grading congestion in each venous flow (suprahepatic, renal, portal) as "absent," "moderate," or "severe," and also calculating the VExUS score.

Eligibility criteria

Qualifiers

Hypoxemia with a PaO₂ (mmHg)/FiO₂ (0.21 to 1.0) ratio <300 mmHg with a positive end-expiratory pressure (PEEP) ≥5 cmH₂O;

Pulmonary edema not fully explained by cardiac failure or fluid overload;

Presence of bilateral pulmonary opacities on chest imaging not fully explained by pleural effusions, atelectasis, or pulmonary nodules.

Disqualifiers

Minor patient (<18 years old)

ECMO (Extracorporeal Membrane Oxygenation)

Hemodynamic instability (mean arterial pressure <60 mmHg)

Respiratory instability (SpO₂ <90% under FiO₂ >90%)

Trial design

Treatments tested in this trial

  • Non-interventionnal study

Treatment groups

30 Participants
are divided into 1 treatment group

Sponsors and collaborators