Remodelling of the Lower Airways in Chronic Cough
ConditionChronic Cough
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorMedical University of Warsaw
About this trial
The aim of the study is to assess if chronic cough leads to injury and remodelling of the airways. We plan to analyse bronchial injury and remodelling in patients with refractory chronic cough lasting longer than 12 month . Assessment of injury mediators will be performed in blood and bronchoalveolar lavage fluid. Remodelling features will be analysed based on chest CT scan and pathologic specimens. Injury of epithelium will be assessed in bronchial biopsy specimens. The relationship between the duration, severity of chronic cough, and bronchial inflammation, damage, remodelling will be analysed.
Eligibility criteria
Qualifiers
age between 18 and 75 years,
chronic cough of at least one year duration, with no previous treatment (at least 2 previous unsuccessful attempts at pharmacological treatment of cough)
negative history of smoking (at least 6 months of abstinence),
negative history of treatment with angiotensin-converting enzyme inhibitors (ACEI),
Disqualifiers
patients less than 18 and more than 75 years of age,
cough lasting less than 12 months,
active smoking or abstinence period of less than 6 months,
respiratory tract infection 6 weeks prior to inclusion or at the time of study conduct - retry inclusion after 6 weeks,
Trial design
Treatments tested in this trial
- chest computed tomography and bronchoscopy
Treatment groups
40 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov