REmote COnditioning in Out-of-Hospital Cardiac Arrest
ConditionOut-Of-Hospital Cardiac Arrest
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorHospices Civils de Lyon
About this trial
Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury.
The objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and/or severe neurological failure.
Eligibility criteria
Qualifiers
Age between 18 and 80 years old
Out-of-hospital cardiac arrest, whatever the initial cardiac rhythm (shockable or non-shockable) or the duration of no-flow and low-flow,
Presence of a witness who may or may not have started cardiopulmonary resuscitation, or patient seen alive in the 30 minutes prior to the cardiac arrest,
Hospitalisation in critical care (intensive care unit or cardiac intensive care unit) for less than 3 hours,
Disqualifiers
Traumatic cardiac arrest
Patient on extracorporeal circulatory assistance
Cardiac arrest for which continuation of resuscitation does not appear justified (unavoidable death, terminal stage of an irreversible disease, etc.)
Contraindication of the use of brachial cuff on both arms (arteriovenous fistula, lymphoedema or severe peripheral vascular pathology, unstable humeral fracture, continuous infusion into an upper limb vein of an essential drug such as a catecholamine, radial arterial catheter for continuous invasive measurement of blood pressure)
Trial design
Treatments tested in this trial
- Remote ischemic conditioning
- No remote ischemic conditioning
Treatment groups
220 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov