Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-85
SponsorUniversity of Nottingham
About this trial
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \[dose\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC.
The goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA.
Participants shall:
Receive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples
Eligibility criteria
Qualifiers
Participant is willing and able to give informed consent for participation in the study
Participant aged 65 - 85
Participant is able to perform RIC independently at home
Disqualifiers
Active cardiovascular or cerebrovascular disease (acute event within the last 12 months)
Atrial fibrillation or other significant arrhythmias
Peripheral Vascular Disease
Haemostatic disorders
Trial design
Treatments tested in this trial
- Remote Ischaemic Conditioning
- Sham Remote Ischaemic Conditioning
Treatment groups
45 Participants
are divided into 3 treatment groupsSponsors and collaborators
University of Nottingham
Lead sponsor
University of Leicester
Collaborator
Source ClinicalTrials.gov