Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorRenJi Hospital
About this trial
Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.
Eligibility criteria
Qualifiers
age 18-75 years
patients received liver transplantation
new onset of proteinuria(defined as 24-hour proteinuria>1g/24h, or Urinary albumin creatinine ratio(UACR)>300mg/g on at least two occasions), and/or renal impairment: eGFR <60 mL/min/1.73 m² at least two occasions, and/or serum creatinine increase ≥50% from baseline
have received renal biopsy in the past 3 months
Disqualifiers
patients received renal transplantation
hepatic failure
severe bleeding risk or platelet <70*109/L
chronic kidney insufficiency with eGFR<30ml/min·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy
Trial design
Treatments tested in this trial
- renal biospy
Treatment groups
369 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov