Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.
Age > 18 years
Within 24 hours of ICU admission following traumatic injury
Received any blood products during initial resuscitation
Lactate > 2 mmol/l at any stage prior to study enrolment
Known intolerance to Sonovue or any other ultrasound contrast agent
Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative
Known CKD 4 or end stage renal failure
Pregnancy