Renin-guided Hemodynamic Management in Patients With Shock
ConditionShock
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversità Vita-Salute San Raffaele
About this trial
Shock is a major risk factor for mortality among patients admitted to intensive care units (ICUs). Since various hemodynamic strategies uniformly delivered to patients with shock have failed to improve clinically relevant outcomes, individualized approaches for shock supported by robust evidence are required. This study will be a prospective, multicenter, parallel-group, single-blind, randomized controlled trial. The investigators will randomly assign 800 critically ill patients requiring norepinephrine infusion to the renin-guided or usual care groups. The investigators hypothesize that renin-guided hemodynamic management, compared to usual care, can reduce a composite of mortality and acute kidney injury (AKI) progression in patients requiring vasopressor support.
Eligibility criteria
Qualifiers
≥18 years old
Admitted to an intensive care unit (ICU)
Requiring norepinephrine infusion at any dose to maintain a mean arterial pressure (MAP) of ≥65 mmHg after initial fluid resuscitation
Expected to stay in the ICU for at least 24 hours
Disqualifiers
Pregnancy
Refused informed consent
Current enrollment into another randomized controlled trial that does not allow concomitant enrollment
Requiring vasopressors for >12 hours before the enrollment
Trial design
Treatments tested in this trial
- Renin-guided hemodynamic management
- Usual care
Treatment groups
800 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov